An experiment was conducted under glasshouse conditions to test the effects of neem-based product in the form of drenches and potato tuber treatments on the growth of potato and population density of the potato cyst nematode Globodera rostochiensis. The soil applications of the biopreparation improved the plant growth and yield of potato, being greatest with 1% Neem Azal. The biggest increase in the yield occurred in the Oxamyl application (15.8%). The biopreparation in concentrations from 0.2% to 1% increased the yield of potatoes from 0.3% to 9.7% compared to the untreated inoculated control. The soil application was relatively more effective in increasing of the yield (0.3%-9.7%) than the potato tuber treatments (0.3%-2.3%). The nematode reproduction was reduced 83.3% with Oxamyl and from 59.8% to 71.0% with Neem Azal treatments.