Objectives of this study were to assess durum wheat genotypes for drought tolerance and to study relationships among different drought tolerance indices under different drought stress conditions. The total of twenty-two durum wheat lines was evaluated in a RCBD experiment with three replications for three cropping seasons (2008–2009; 2009–2010 and 2010–2011). Different drought indices such as tolerance (TOL), mean productivity (MP), mean relative performance (MRP), stress susceptibility index (SSI), modified severity stress index (SSSI), geometric mean productivity (GMP), stress tolerance index (STI), yield stability index (YSI), relative efficiency index (REI) and drought response index (DRI) were determined based on yields under drought and non-drought conditions. The studied genotypes showed considerable variation in performance and tolerated various drought conditions that could be exploited in the durum wheat breeding program. The screening of genotypes for drought tolerance in environments with a greater value of stress intensity (SI) will be more efficient in the grouping of indices and genotype selection. The indices were classified into groups (G1 and G2). The group G1, which consisted of the indices REI, STI, MRP, GMP, DRI and YSI, distinguished genotypes with higher yield in different levels of drought stress. The durum breeding line nos. 1, 11, 10, 13, 8, 9, and 12 were superior based on the group G1 and could be regarded for further evaluation in drought-prone environments.