Poor agronomic practices coupled with herbicide mismanagement influence crop performance, yield, weed infestation and environmental hazards. Thus, field experiments were carried out to investigate the effect of spacing and reduced levels of butachlor on weed control and yield of NERICA 1 rice (Oryza sativa L. x Oryza glaberrima L). The experiments were conducted in the 2011 rainy season at the Teaching and Research Farm of the Department of Crop Production and Horticulture, Modibbo Adama University of Technology, Yola, and Lake Gerio, Yola in the 2012 dry season. Yola is located between latitude 9^o14′ N and longitude 12^o28′ E in the Northern Guinea Savanna ecological zone of Nigeria. Treatments consisted of four spacings (20 cm x 20 cm, etc.) and four butachlor levels (3, 2, 1, and 0 kg ha‑1 a.i.). The experiments were laid out in a split-plot design with spacings assigned to the main plot and butachlor levels assigned to the sub-plot and were replicated three times. Data were taken on percentage establishment, number of leaves per plant, general weed cover, panicle length and grain yield per hectare. Data generated were subjected to analysis of variance. Means showing a significant F-test were separated using LSD. Results obtained showed that butachlor at 1 kg ha‑1 and 14 cm x 14 cm spacing gave the highest grain yield of 1441 kg ha‑1 and maximum weed control. They are, therefore, recommended for adoption by farmers in Yola and similar environments.