The article presents field research results on the effectiveness of different moisture and nutrition conditions at the cultivation of early potato under drip irrigation in southern Ukraine. The scheme of the experiment included the treatment with the complex Mochevyn K as an additional control and different methods and correlation of fertilizers Plantafol (treatment of tubers before planting, fertilizing, at budding and their combination), as well as different soil moisture conditions (irrigation rates of 100 and 200 m³/ha). Studies have shown that the average yield of early potato without irrigation was 10.44 t/ha. Moisture conditions significantly affected the yield of young tubers – irrigation at a rate of 200 m³/ha provided 21.61 t/ha, whereas reducing the irrigation rate to 100 m³/ha led to a decrease in yield – 19.86 t/ha. The first treatment of planting tubers, treatment of plants at sproutingand during budding provided almost the same yield. The second and the third treatments of plants and tubers did not lead to a significant increase in yield. The highest productivity of potato was provided by Plantafol treatment of tubers and combination of tuber treatment with foliar feedingat mass sprouting phase with a 200 m³/ha irrigation rate for two years: 24.16 and 23.22 t/ha.