Weed interference is a major threat to rice production, leading to high yield reduction and reduced profitability. Therefore, field experiments were conducted to evaluate the effect of the different timings of weed control on the growth and yield of upland rice in the 2015 and 2016 cropping seasons. The treatments consisted of periods when the crop was allowed to be weed-infested for the first 3, 6 and 9 weeks after sowing (WAS) and periods when the weeds were controlled for the first 3, 6 and 9 WAS. Two treatments of weed infestation and weed control until harvest were also included as the checks in a randomized complete block design with three replications. In both years, rice grain yields ranged from 0.6 to 0.8 t ha^-1 in plots kept weed-infested until harvest, and from 3.5 to 3.9 t ha^-1 in plots kept weed-free until harvest, indicating a 79–83% yield loss with uncontrolled weed growth. Weed infestation for the first 3 WAS did not cause a significant reduction in the growth and yield of rice provided the weeds were removed thereafter. However, the delay in weed control until 9 WAS reduced rice growth and resulted in irrevocable yield reduction. It was only necessary to remove the weeds between 3 and 9 WAS for optimum grain yield, as no significant yield increase was observed in weed control after 9 WAS in both years. This study showed that weed control between 3 and 9 WAS would give the optimum growth and yield of upland rice.