During 2019 and 2020, field experiments were performed on sweet pepper crops to determine the efficacy of chemical insecticides (lambda-cyhalothrin, flubendiamide), semi-synthetic (emamectin benzoate), and biological pesticide (azadirachtin) in controlling cotton bollworm (Helicoverpa armigera). The experiments were performed in a randomized complete block design with four replications according to the standard EPPO method at the site of Veliko Gradište (Serbia). Flubendiamide was applied at a rate of 50 g/ha, lambda-cyhalothrin at a rate of 7.5 g/ha, emamectin benzoate at a rate of 375 g/ha, and azadirachtin at a rate of 0.75 g/ha. The intensity of the 2^nd generation cotton bollworm infestation on sweet pepper at this locality was higher during 2020 compared to 2019. After performing two treatments for the 2^nd generation, flubendiamide showed the highest efficacy, ranging from 92.42% (3 days after treatment – DAT, 2020) to 95.56% (9DAT, 2019). Lambda-cyhalothrin had a satisfactory efficacy in the range of 81.93% (9DAT, 2020) to 90.63% (3DAT, 2019), and emamectin benzoate showed similar efficacy from 80.72% (9DAT, 2020) to 90.63% (3DAT, 2019). Azadirachtin could gain a significant place as a botanical insecticide in integrated pest management programs for sweet pepper protection from H. armigera. However, it statistically showed a significantly lower efficacy than other insecticides (77.27%: 3DAT, 2020 to 86.67%: 9DAT, 2019).