The present research in the study of the effect of application of natural bio-stimulants and slow-release fertilizers on commercial production of begonia (Begonia semperflorens) saplings. Two types of containers were deployed in the production process, whereas the results of the experimental research showed that the application of both slow-release fertilizers and natural bio-stimulants in further production is only justifiable in cases when large volume containers are deployed in commercial production of sapling.