The preliminary results of a two-year comparative investigation of two genotypes of ribwort-plantain in the agroecological conditions of west Serbia (Gorobilje), south Banat (Pančevo) are given. Genotype originating from the international exchange (marked with 'D') was compared with 'domestic' genotype which has been raised at the Medicinal Plants Research Institute 'Dr Josif Pančić', Belgrade, for more than ten years. Both genotypes have been monitored during two years of the research - 1998 and 1999. 'D' genotype is more early growing than 'domestic' genotype. That earliness is about one month in both years of the research. This genotype has broader leaves but is more susceptible to plant diseases. 'Domestic' genotype is higher yielding and its yield is less influenced by growing conditions. The differences in dry lief yield range up to 50% in favour of 'domestic' genotype. This genotype has much higher content of basic active matter aucubin.